Development of exosomes biogenesis and secretion mechanisms / 解放军医学杂志

Exosomes are nano-sized membrane vesicles (30-100nm in diameter) actively secreted by many cell types and generally exist in many body fluids that contain a variety of cargos,such as protein,lipid and nucleic acid.Exosomes play an important role in cross-communication between different cells and closely associate with the development,treatment and prognostic of many diseases.Recently,exosomes have becoming a hot spot in medical research.An overview of current understanding in biogenesis and secretion mechanism,as well as the regulation of exosomes has been laid in present paper.